Extrachromosomal DNAs (ecDNAs) are a pervasive feature found in cancer and contain oncogenes and their corresponding regulatory elements. Their unique structural properties allow a rapid amplification of oncogenes and alter chromatin accessibility. leading to tumorigenesis and malignant development. The uneven segregation of ecDNA during cell division enhances intercellular genetic he... https://www.roneverhart.com/Hosa-SH-8X4-25-Stage-Box-Non-locking-8x4-25-p37478/